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Updated: Jun 3, 2026
09:36
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
Published on: April 10, 2018
Non-coding RNA networks underlying cognitive disorders across the lifespan
Irfan A Qureshi1, Mark F Mehler
1Rosyln and Leslie Goldstein Laboratory for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA. irfan@jhu.edu
Trends in Molecular Medicine
|March 18, 2011
Summary
Non-coding RNAs (ncRNAs) regulate brain functions, including cognition and behavior. This review explores diverse ncRNAs, their roles in brain development, plasticity, aging, and cognitive disorders.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Non-coding RNAs (ncRNAs) are crucial regulators of gene expression.
- ncRNA regulatory networks are increasingly recognized for their role in neurobiology.
- Cognitive and behavioral processes are influenced by ncRNA activity.
Purpose of the Study:
- To review novel and diverse classes of short and long ncRNAs.
- To discuss the molecular functions and life cycles of ncRNAs.
- To examine the role of ncRNA circuitry in brain function and disorders.
Main Methods:
- Literature review of ncRNA research.
- Analysis of ncRNA involvement in neurodevelopment, plasticity, and aging.
- Exploration of ncRNA roles in cognitive disorders.
Main Results:
- Emergence of numerous novel ncRNA classes and subclasses.
- ncRNAs mediate critical neurobiological functions including development, plasticity, stress response, and aging.
- ncRNA dysregulation is implicated in cognitive disorders.
Conclusions:
- ncRNAs are vital players in normal brain function.
- ncRNA networks offer potential therapeutic targets for cognitive and neurodegenerative diseases.
- Further research into ncRNA functions is essential for understanding brain health and disease.
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