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Dissecting the Non-human Primate Brain in Stereotaxic Space
Published on: July 16, 2009
The development of small primate models for aging research.
Kathleen E Fischer, Steven N Austad1
1Department of Physiology, University of Texas Health Science Center in San Antonio, USA.
ILAR Journal
|March 18, 2011
Summary
Smaller, shorter-lived nonhuman primates (NHP) offer advantages for aging research over traditional models like rhesus macaques. Species like mouse lemurs and galagos show promise for studying human aging.
Area of Science:
- Gerontology
- Comparative Biology
- Primate Models
Background:
- Traditional nonhuman primate (NHP) aging research primarily uses rhesus macaques.
- The rhesus macaque's long lifespan, low reproductive rate, and large size present challenges for aging studies.
- Smaller, faster-developing NHP species could offer cost and time efficiencies.
Purpose of the Study:
- To identify suitable small, short-lived nonhuman primate models for human aging research.
- To evaluate prosimian and callitrichid species based on specific criteria for aging studies.
Main Methods:
- Defined
- small
- primates as weighing less than 500 g.
- Assessed species based on availability, ease of maintenance, potential for genetic manipulation, and physiological similarities to human aging.
- Focused on prosimians and callitrichids, including Microcebus murinus, Galago senegalensis, and Callithrix jacchus.
Main Results:
- Identified three species (Microcebus murinus, Galago senegalensis, Callithrix jacchus) as strong candidates for NHP aging research.
- Highlighted Cebus spp. as a potential model due to their relatively long lifespan for their body size.
Conclusions:
- Microcebus murinus, Galago senegalensis, and Callithrix jacchus warrant further investigation as major NHP models for aging research.
- Exploring diverse NHP species can optimize aging studies, offering practical and scientific benefits.
