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Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

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Tip-enhanced Raman mapping with top-illumination AFM.

K L Andrew Chan¹, Sergei G Kazarian

¹Department of Chemical Engineering, Imperial College London, SW7 2AZ, UK.

|March 18, 2011

Summary

Tip-enhanced Raman scattering (TERS) can now image non-transparent samples using an upright microscope. This advancement in TERS nano-imaging offers high spatial resolution for nanoscale materials.

Area of Science:

Nanotechnology
Chemical Imaging
Spectroscopy

Background:

Tip-enhanced Raman scattering (TERS) typically uses an inverted configuration, limiting analysis to transparent samples.
Existing reflection-mode TERS often requires system customization.

Purpose of the Study:

To demonstrate TERS nano-imaging in reflection mode using an upright microscope.
To enable chemical analysis of non-transparent nanoscale materials.

Main Methods:

Utilized an upright microscope with a gold-coated silicon atomic force microscope (AFM) cantilever.
Employed a standard integrated AFM/Raman system with minimal modifications.

Main Results:

Achieved TERS nano-images of a single-walled carbon nanotube.

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Obtained a spatial resolution of approximately 20-50 nm.

Conclusions:

Demonstrated the feasibility of TERS nano-imaging in reflection mode with an upright microscope.
Highlighted the potential for studying non-transparent nanoscale materials without extensive system modifications.