Related Experiment Video
Updated: Jun 3, 2026

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
Published on: November 11, 2016
Characterization of interaction between tricyclic structures containing pharmaceuticals, their models and humic
M Klavins1, L Ansone, O Purmalis
1Department of Environmental Sciences, University of Latvia, 19 Raina Blvd., LV 1586, Riga, Latvia. maris.klavins@lu.lv
Abstract:
Their persistence and wide consumption identify pharmaceuticals as "emerging pollutants". The complexation of pharmaceuticals containing adamantine ring structures and their model substances with humic acids (HA) of different origins was compared using fluorescence spectroscopy as a function of pH, humic acid concentration, ionic strength, and molecular mass of HA. Binding constants between the studied pharmaceuticals and humic acids were calculated. A combination of dynamic and static quenching processes as indicated by nonlinear Stern-Volmer plots and high K(d) values were positively correlated with the concentration of carboxyl groups in the studied humic acids. For basic functional group-containing pharmaceuticals, the complexation was driven by cation exchange and hydrophobic interactions depending on the properties of the interacting compounds.
Related Concept Videos
Multicompartment Models: Overview
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
Pharmacodynamic Models: Direct Effect Model and Indirect Response Model
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship
Pharmacodynamic Models: Overview
Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance
A recent model describes pravastatin's hepatobiliary excretion, mediated...
Model Approaches for Pharmacokinetic Data: Compartment Models
Two primary types of compartment models are recognized: mammillary and catenary. The more...
