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Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
Published on: May 9, 2013
Outcomes associated with carotid pseudo-occlusion
Toshiyasu Ogata1, Masahiro Yasaka, Yuka Kanazawa
1Department of Cerebrovascular Medicine, Center and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan. toshi.ogata1@gmail.com
Cerebrovascular Diseases (Basel, Switzerland)
|March 18, 2011
Summary
Patients with carotid pseudo-occlusion (PO) face a poorer prognosis, experiencing more strokes, heart attacks, or death compared to those with carotid artery stenosis (CS). This highlights a significant difference in outcomes for PO patients.
Area of Science:
- Vascular Surgery
- Cardiology
- Neurology
Background:
- Carotid artery stenosis (CS) is a significant risk factor for stroke.
- Carotid pseudo-occlusion (PO) is a distinct condition that may have different prognostic implications.
Purpose of the Study:
- To compare the prognosis of patients with carotid pseudo-occlusion (PO) versus those with severe carotid artery stenosis (CS) without PO.
- To determine if PO is associated with a different clinical outcome compared to CS.
Main Methods:
- Cerebral angiography identified patients with severe CS (≥70%) or PO.
- A primary endpoint of stroke, myocardial infarction, or death was tracked.
- Kaplan-Meier analysis and multivariate analysis compared outcomes between the PO and CS groups.
Main Results:
- 337 patients were analyzed (34 in PO group, 303 in CS group) with a mean follow-up of 32 months.
- The PO group had a higher incidence of diabetes mellitus.
- Kaplan-Meier analysis showed a higher frequency of the primary outcome in the PO group.
- Multivariate analysis confirmed significantly poorer outcomes for patients in the PO group (p = 0.013).
Conclusions:
- Patients with carotid pseudo-occlusion (PO) experience a higher rate of neurological and cardiac events, and mortality, compared to patients with carotid artery stenosis (CS).
- PO represents a distinct clinical entity with a worse prognosis than severe CS alone.
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