Hepatocellular adenomas: current update on genetics, taxonomy, and management

Area of Science:

• Hepatology
• Oncology
• Radiology

Background:

• Hepatocellular adenomas (HCAs) are rare benign liver tumors.
• They predominantly affect young women.
• Recent research has refined HCA classification.

Purpose of the Study:

• To review the current classification of hepatocellular adenomas.
• To emphasize cross-sectional imaging findings for each subtype.
• To discuss management strategies for HCAs.

Main Methods:

• Comprehensive literature review.
• Analysis of pathological and cytogenetic data.
• Correlation of imaging findings with HCA subtypes.

Main Results:

• HCAs are classified into 3 distinct subtypes.
• Each subtype exhibits unique epidemiological, histopathological, and oncogenetic profiles.
• Characteristic cross-sectional imaging findings aid in subtype differentiation.

Conclusions:

• Contemporary HCA classification aids in understanding pathogenesis.
• Accurate diagnosis relies on integrating clinical, pathological, and imaging data.
• Tailored management strategies are informed by HCA subtype and imaging features.