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Related Concept Videos

Upstream Processing01:27

Upstream Processing

Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
Downstream Processing01:29

Downstream Processing

Downstream processing begins once fermentation is complete and involves a series of steps to recover and purify products such as acids, vitamins, antibiotics, or proteins.Cell HarvestingFor example, for intracellular protein-based products, the first step is harvesting the cells. This is typically achieved using centrifugation or filtration to separate the cells from the liquid phase.Cell Disruption for Intracellular ProductsIf the target product is intracellular, the harvested cells must be...
Fast Reactions01:27

Fast Reactions

Fast reactions occurring in times shorter than the time needed to mix reactants pose a unique challenge for investigation. In a liquid-phase continuous-flow system, reactants A and B are swiftly pushed into the mixing chamber, where mixing occurs within 1 ms. The reaction mixture then flows through an observation tube, and one measures light absorption to determine species concentrations at various points of the tube. This method is most appropriate when relatively large volumes of reactants...

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Related Experiment Video

Updated: Jun 3, 2026

Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor
09:49

Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor

Published on: April 6, 2016

Enzymatic processing in microfluidic reactors.

Masaya Miyazaki1, Takeshi Honda, Hiroshi Yamaguchi

  • 1Nanotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tosu, Saga 841-0052, Japan. m.miyazaki@aist.go.jp

Biotechnology & Genetic Engineering Reviews
|March 18, 2011
PubMed
Summary
This summary is machine-generated.

Microreaction technology offers innovative solutions for enzyme processes, overcoming stability and efficiency challenges. Enzyme microreactors are highlighted as efficient tools for developing these advanced chemical processes.

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Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies

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Last Updated: Jun 3, 2026

Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor
09:49

Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor

Published on: April 6, 2016

Aqueous Droplets Used as Enzymatic Microreactors and Their Electromagnetic Actuation
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Aqueous Droplets Used as Enzymatic Microreactors and Their Electromagnetic Actuation

Published on: August 28, 2017

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies
12:55

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies

Published on: November 27, 2013

Area of Science:

  • Interdisciplinary science and engineering
  • Chemical engineering
  • Biotechnology

Background:

  • Enzymes are eco-friendly catalysts with high analytical potential but face commercialization hurdles due to stability and cost issues.
  • Innovation in process engineering is needed for enzymatic reactions.
  • Microreaction devices offer promising solutions for developing enzyme processes.

Purpose of the Study:

  • To review recent advances in microchannel reaction technologies, focusing on enzyme microreactors.
  • To discuss the manufacturing and advantages of microreactors compared to conventional reactors.
  • To cover fundamental techniques and applications of enzyme microreactors in chemical processing.

Main Methods:

  • Review of recent scientific literature on microchannel reaction technologies and enzyme microreactors.
  • Discussion of microreactor manufacturing processes.
  • Analysis of advantages and applications of enzyme microreactors.

Main Results:

  • Microreactors provide significant advantages over conventional reactors for enzymatic processes.
  • Detailed discussion on manufacturing techniques and fundamental principles of enzyme microreactors.
  • Exploration of diverse applications in chemical processing.

Conclusions:

  • Enzyme microreactors represent a significant advancement in process engineering for enzymatic reactions.
  • Microreaction technology facilitates overcoming limitations in enzyme stability, cost, and efficiency.
  • This multidisciplinary field holds substantial potential for future chemical processing innovations.