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Updated: Jun 3, 2026

A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice
Published on: July 15, 2025
[Women's reproductive related disorders: a new proposal for the mental health field]
1Instituto Nacional de Perinatología Isidro Espinoza de los Reyes, México, D.F. flores_ramos@hotmail.com
Abstract:
Recently, a research group has suggested the existence of women's disorders that may be grouped together as reproductive-related disorders, characterized by their timing (related to reproductive processes), shared vulnerability, and a common pathophysiology. Symptoms of reproductive-related disorders could be different among women, but are consistent within each individual woman and always present during reproductive-life periods including pregnancy, postpartum, and the premenstrual and perimenopausal periods. An association between hormonal changes and affective disorders is suggested as a physiopathology process of reproductive-related disorders, with an abnormal adaptation to hormonal changes in vulnerable women. In this paper we describe some characteristics of premenstrual dysphoria disorder, postpartum depression, and perimenopausal depression. A proposed pathophysiology of these disorders is described and pharmacologic options for treatment are also reviewed.
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