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Related Experiment Video

Updated: Jun 3, 2026

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

Thalamic stimulation for tremor: can target determination be improved?

Eric Bardinet1, Hayat Belaid, David Grabli

  • 1Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, Paris, France. eric.bardinet@upmc.fr

Movement Disorders : Official Journal of the Movement Disorder Society
|March 18, 2011
PubMed
Summary

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High frequency stimulation of the ventral intermedius nucleus (Vim) precisely targets essential tremor. Individualized targeting using a 3D brain atlas improves accuracy over statistical methods, potentially enhancing clinical outcomes.

Area of Science:

  • Neurosurgery
  • Neurology
  • Medical Imaging

Background:

  • High-frequency stimulation of the ventral intermedius nucleus (Vim) is a key treatment for postural tremor.
  • Current Vim targeting relies on statistical methods, which may lack individual precision.

Purpose of the Study:

  • To compare the accuracy of statistical versus individual targeting methods for Vim electrode placement.
  • To evaluate the impact of a histology-based 3D deformable brain atlas for individual Vim localization.

Main Methods:

  • Compared statistical and individual Vim targeting in 29 patients undergoing surgery for essential tremor.
  • Utilized a 3D deformable brain atlas adapted to individual patient MR images for individual target determination.
  • Calculated Pythagorean distance between statistical and individual targets and assessed perioperative stimulation effects.

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Related Experiment Videos

Last Updated: Jun 3, 2026

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

Localizing Function-specific Targets for Transcranial Magnetic Stimulation in the Absence of Navigation Equipment
09:30

Localizing Function-specific Targets for Transcranial Magnetic Stimulation in the Absence of Navigation Equipment

Published on: May 23, 2025

Main Results:

  • Individual and statistical targets differed by >1.5 mm in 24 cases, with the individual target used for definitive implantation in 79%.
  • When the distance was <1.5 mm (11 cases), the statistical target was used in 73%.
  • Individual targets were located >2 mm medial to statistical targets in 86% of cases, suggesting potential overestimation of laterality in statistical methods.

Conclusions:

  • Statistical Vim targeting may be inaccurate, potentially leading to suboptimal clinical results due to overestimated laterality.
  • Individualized targeting using deformable brain atlases is crucial for precise Vim electrode placement.
  • Surgical planning should consider microelectrode trajectories medial to the statistical target to optimize Vim stimulation for essential tremor.