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Updated: Jan 26, 2026
08:49
External Cephalic Version: Is it an Effective and Safe Procedure?
Published on: June 6, 2020
15.8K
Propofol for procedural sedation/anaesthesia in neonates
Prakeshkumar S Shah1, Vibhuti S Shah
1Department of Paediatrics and Department of Health Policy, Management and Evaluation, Rm 775A, University of Toronto, 600 University Avenue, Toronto, Ontario, Canada, M5G 1XB.
The Cochrane Database of Systematic Reviews
|March 18, 2011
Summary
Propofol may offer faster recovery for neonatal procedures, but more research is needed to confirm its safety and efficacy compared to traditional agents like morphine. Current evidence is insufficient for practice recommendations.
Area of Science:
- Neonatal Anesthesiology
- Pharmacology
- Evidence-Based Medicine
Background:
- Neonates in NICU often undergo procedures requiring sedation/analgesia.
- Opioids are common but have adverse effects.
- Propofol is used in older populations, but its neonatal use is undefined.
Purpose of the Study:
- To evaluate propofol's efficacy and safety for neonatal procedures.
- To compare propofol against placebo, no treatment, or alternative agents.
- To conduct subgroup analyses based on administration, control agent, procedure type, and gestational age.
Main Methods:
- Searched MEDLINE, EMBASE, and CENTRAL databases (up to Sept 2010).
- Included randomized or quasi-randomized controlled trials involving neonates.
- Data collected and analyzed per Cochrane Neonatal Review Group standards.
Main Results:
- One trial (63 neonates) compared propofol to morphine-atropine-suxamethonium.
- No significant difference in intubation attempts.
- Shorter preparation, procedure, and recovery times with propofol; no significant side effects observed in limited data.
Conclusions:
- Insufficient evidence to recommend propofol for neonates.
- Further research on pharmacokinetics and safety/efficacy is required.
- Need for randomized controlled trials to establish safe dosing and effectiveness.
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