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Hepatitis B vaccination during pregnancy for preventing infant infection

Ussanee S Sangkomkamhang1, Pisake Lumbiganon, Malinee Laopaiboon

  • 1Department of Obstetrics and Gynaecology, Khon Kaen Hospital, Srichan Road, Maung, Khon Kaen, Thailand, 40000.

The Cochrane Database of Systematic Reviews
|March 18, 2011
PubMed

Insights

No studies were found on hepatitis B vaccination for pregnant women to prevent infant infection. More research is needed to guide clinical practice for hepatitis B prevention in newborns.

Area of Science:

  • Hepatology
  • Immunology
  • Public Health

Background:

  • Infant hepatitis B infection poses long-term risks, including chronic infection, cirrhosis, and liver cancer.
  • Perinatal transmission is a significant route for hepatitis B virus (HBV) infection in infants.

Purpose of the Study:

  • To evaluate the efficacy and safety of administering hepatitis B vaccine to pregnant women.
  • To determine the vaccine's effectiveness in preventing hepatitis B virus infection in infants.

Main Methods:

  • A systematic search was conducted using the Cochrane Pregnancy and Childbirth Group's Trials Register up to December 2010.
  • Included were randomized controlled trials (RCTs) comparing hepatitis B vaccination in pregnancy to placebo or no treatment.
  • Excluded were quasi-RCTs and crossover studies; trial eligibility was independently assessed.

Main Results:

  • The review identified no eligible randomized controlled trials (RCTs) that met the inclusion criteria.
  • Consequently, no data were available to assess the effectiveness or adverse effects of hepatitis B vaccination during pregnancy.

Conclusions:

  • There is a lack of RCTs evaluating hepatitis B vaccination in pregnant women for infant protection.
  • Further well-designed randomized clinical trials are necessary to establish the safety and efficacy of this intervention.
  • Current evidence does not support clinical guidance on antenatal hepatitis B vaccination for infant infection prevention.
Abstract

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