Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term functional and radiological outcomes among survivors of ankylosing spondylitis-associated cervical spine fractures: a cross-sectional follow-up study.

North American Spine Society journal·2026
Same author

Radiotherapy quality assurance in the PRO-GLIO trial: results from a dummy run comparing experts across twelve institutions in two Scandinavian countries.

Clinical and translational radiation oncology·2026
Same author

Subaxial cervical spine fractures in ankylosing spondylitis: management and outcomes from a 10-year population-based cohort.

Journal of neurosurgery. Spine·2026
Same author

Spatial-temporal recurrence patterns of grade 4 glioma using deep learning integrated multiparametric MRI and molecular pathology.

NPJ precision oncology·2026
Same author

Case Report: Proton beam therapy - friend or foe for patients with <i>IDH</i>-mutated WHO grade 2 and 3 gliomas?

Frontiers in oncology·2026
Same author

European neuro-oncology quality assessment (ENOQUA): A European organization for the research and treatment of cancer (EORTC) brain tumor group research project.

Neuro-oncology practice·2026
Same journal

Biphenotypic Sinonasal Sarcoma With a Novel PAX3::MAML2 Fusion.

Genes, chromosomes & cancer·2026
Same journal

An Affordable and Efficient In-House Approach for Detecting Gene Fusions in Bone and Soft Tissue Tumors Using a Custom Capture Panel and Nanopore Sequencing.

Genes, chromosomes & cancer·2026
Same journal

PKMYT1 in Cancer: Beyond Cell Cycle Checkpoints to Context-Dependent Therapeutic Vulnerability.

Genes, chromosomes & cancer·2026
Same journal

Associations of Dietary Intake Traits and Aging Indicators With Colorectal Cancer: A Mendelian Randomization Study.

Genes, chromosomes & cancer·2026
Same journal

Primary Tumor-Associated Loss of the Y Chromosome and Clinical Outcome in Metastatic Colorectal Cancer.

Genes, chromosomes & cancer·2026
Same journal

Cytogenetic and Molecular Analysis of a "Double-Hit" RUNX1 Including a RUNX1 p.Trp279* and a Cryptic Novel t(6;21)(q25;q22)/RUNX1::ARID1B in Acute Myeloid Leukemia.

Genes, chromosomes & cancer·2026
See all related articles

Related Experiment Video

Updated: Jun 3, 2026

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas
06:27

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas

Published on: May 9, 2025

Genomic aberrations in diffuse low-grade gliomas.

Hanne-Sofie S Dahlback1, Ludmila Gorunova, Petter Brandal

  • 1Section for Cancer Cytogenetics, Institute for Medical Informatics, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway. h.s.s.dahlback@medisin.uio.no

Genes, Chromosomes & Cancer
|March 18, 2011
PubMed
Summary
This summary is machine-generated.

Diffuse low-grade gliomas have distinct genetic profiles beyond current classification. Complex chromosomal aberrations correlate with more aggressive tumor behavior, suggesting potential for targeted therapies.

More Related Videos

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
09:17

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

Related Experiment Videos

Last Updated: Jun 3, 2026

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas
06:27

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas

Published on: May 9, 2025

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
09:17

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

Area of Science:

  • Neuro-oncology
  • Cancer Genetics
  • Molecular Pathology

Background:

  • Current diffuse low-grade glioma classification relies on histopathology, which poorly predicts clinical outcomes.
  • Understanding the genetic basis of these tumors is crucial for improved diagnosis and treatment.

Purpose of the Study:

  • To investigate the genetic landscape of WHO Grade II astrocytomas, oligodendrogliomas, and oligoastrocytomas.
  • To identify genetic differences that may explain variable clinical behavior.
  • To explore the potential of genetic aberrations in predicting tumor aggressiveness.

Main Methods:

  • G-band chromosome analysis and high-resolution comparative genomic hybridization (HR-CGH) were performed on 38 diffuse low-grade gliomas.
  • Karyotyping and HR-CGH identified chromosomal abnormalities, including losses, gains, and structural rearrangements.
  • Specific attention was given to gemistocytic astrocytomas, a subgroup with known aggressive potential.

Main Results:

  • 41% of tumors exhibited abnormal karyotypes, with distinct patterns in astrocytomas, oligodendrogliomas, and oligoastrocytomas.
  • Common aberrations included losses of chromosomes X, Y, 3, 4, 6, 11 and gains of 8, 12. HR-CGH revealed additional frequent losses at 1p, 17q, 19q and gains at 7q, 10p, 11q, 20p.
  • Tumors with complex chromosomal aberrations showed a trend towards more aggressive behavior (shorter progression-free survival) compared to those with simple aberrations.

Conclusions:

  • Diffuse low-grade gliomas comprise genetically distinct subgroups not captured by current histopathological classification.
  • Genetic complexity appears to be a marker for more aggressive tumor behavior in low-grade gliomas.
  • These findings may aid in identifying patients who could benefit from early therapeutic intervention based on their genetic profile.