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Updated: Jun 3, 2026
Polymeric Microneedle Array Fabrication by Photolithography
Published on: November 17, 2015
Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer
Shaun D Gittard1, Philip R Miller, Ryan D Boehm
1Joint Department of Biomedical Engineering, University of North Carolina State University, Campus Box 7115, Raleigh, NC 27695-7115, USA.
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Due to their ability to serve as fluorophores and drug delivery vehicles, quantum dots are a powerful tool for theranostics-based clinical applications. In this study, microneedle devices for transdermal drug delivery were fabricated by means of two-photon polymerization of an acrylate-based polymer. We examined proliferation of cells on this polymer using neonatal human epidermal keratinocytes and human dermal fibroblasts. The microneedle device was used to inject quantum dots into porcine skin; imaging of the quantum dots was performed using multiphoton microscopy.
