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[Drug eruption due to iohexol (Omnipaque)]
1Department of Dermatology, Doai Memorial Hospital, Tokyo.
Rinsho Hoshasen. Clinical Radiography
|April 1, 1990
Summary
Iohexol (Omnipaque) caused a maculopapular rash in three patients undergoing drip infusion pyelography. Skin tests confirmed Iohexol as the trigger, ruling out other contrast agents and stabilizers.
Area of Science:
- Radiology
- Dermatology
- Pharmacology
Background:
- Drip infusion pyelography is a diagnostic imaging procedure.
- Iodinated contrast media are commonly used in radiology.
- Adverse drug reactions to contrast media can occur.
Observation:
- Three patients developed a disseminated maculopapular eruption.
- The rash appeared 5 to 6 days post-administration of Iohexol (Omnipaque).
Findings:
- Skin tests definitively identified Iohexol as the causative agent.
- Other iodinated contrast media tested negative.
- Trometamol, an Omnipaque stabilizer, also yielded negative skin tests.
Implications:
- Highlights the potential for Iohexol-induced hypersensitivity reactions.
- Emphasizes the importance of specific allergen identification in contrast media reactions.
- Informs clinical practice regarding patient monitoring after Iohexol administration.