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Updated: Jun 3, 2026

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
Published on: October 15, 2019
Wavelength-selective caged surfaces: how many functional levels are possible?
Verónica San Miguel1, Christian G Bochet, Aránzazu del Campo
1Max-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128 Mainz, Germany.
Abstract:
The possibility of wavelength-selective cleavage of seven photolabile caging groups from different families has been studied. Amine-, thiol-, and carboxylic-terminated organosilanes were caged with o-nitrobenzyl (NVOC, NPPOC), benzoin (BNZ), (coumarin-4-yl)methyl (DEACM), 7-nitroindoline (DNI, BNI), and p-hydroxyphenacyl (pHP) derivatives. Caged surfaces modified with the different chromophores were prepared, and their photosensitivity at selected wavelengths was quantified. Different pairs, trios, and quartets of chromophore combinations with wavelength-selective photoresponse were identified. Our results show, for the first time, the possibility of generating surfaces with up to four different and independently addressable functional levels. In addition, this manuscript presents the first systematic comparison of the photolytic properties of different photolabile groups under different irradiation conditions.
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