Does atrial natriuretic factor contribute to the progression of renal disease?

In chronic renal failure, non-immunological mechanisms may cause disease progression. It is postulated that the high plasma levels of atrial natriuretic factor which occur in some patients with chronic renal impairment are biologically active. They would not only serve to maintain sodium balance but also alter glomerular haemodymanics and enhance proteinuria to the long-term detriment of renal function.