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Related Experiment Video

Updated: Jun 3, 2026

Detection and Isolation of Apoptotic Bodies to High Purity
12:17

Detection and Isolation of Apoptotic Bodies to High Purity

Published on: August 12, 2018

Measuring and modeling apoptosis in single cells.

Sabrina L Spencer1, Peter K Sorger

  • 1Center for Cell Decision Processes, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

Cell
|March 19, 2011
PubMed
Summary

Mathematical models and single-cell data advance the study of apoptosis, a crucial cell death process. Research over the past decade has clarified key mechanisms like caspase activation and cell-to-cell variability in death timing.

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Area of Science:

  • Cellular Biology
  • Biochemistry
  • Systems Pharmacology

Background:

  • Cell death is fundamental to tissue development, disease processes, and drug responses.
  • Apoptosis, a key form of programmed cell death, requires precise molecular regulation.
  • Understanding apoptosis is critical for both developmental biology and therapeutic interventions.

Purpose of the Study:

  • To review advancements in studying apoptosis over the last decade.
  • To highlight the application of mathematical modeling and quantitative single-cell data.
  • To discuss key mechanistic insights and future challenges in the field.

Main Methods:

  • Review of recent scientific literature focusing on apoptosis research.
  • Analysis of studies employing mathematical models to simulate cell death pathways.

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Quantification of Efferocytosis by Single-cell Fluorescence Microscopy
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Quantification of Efferocytosis by Single-cell Fluorescence Microscopy

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Flow Cytometric Analysis of Apoptotic Biomarkers in Actinomycin D-Treated SiHa Cervical Cancer Cells
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Flow Cytometric Analysis of Apoptotic Biomarkers in Actinomycin D-Treated SiHa Cervical Cancer Cells

Published on: August 26, 2021

Related Experiment Videos

Last Updated: Jun 3, 2026

Detection and Isolation of Apoptotic Bodies to High Purity
12:17

Detection and Isolation of Apoptotic Bodies to High Purity

Published on: August 12, 2018

Quantification of Efferocytosis by Single-cell Fluorescence Microscopy
06:15

Quantification of Efferocytosis by Single-cell Fluorescence Microscopy

Published on: August 18, 2018

Flow Cytometric Analysis of Apoptotic Biomarkers in Actinomycin D-Treated SiHa Cervical Cancer Cells
13:53

Flow Cytometric Analysis of Apoptotic Biomarkers in Actinomycin D-Treated SiHa Cervical Cancer Cells

Published on: August 26, 2021

  • Integration of quantitative, often single-cell, experimental data with computational approaches.

    • Main Results:

    • Detailed understanding of the delay period following pro-death stimuli.
    • Elucidation of the control mechanisms governing mitochondrial outer membrane permeabilization.
    • Characterization of the switch-like activation dynamics of effector caspases.
    • Quantification of variability in apoptosis timing and probability across individual cells.

    Conclusions:

    • Mathematical modeling and quantitative data have significantly advanced apoptosis research.
    • Key molecular events and cellular behaviors in apoptosis are better understood.
    • Significant challenges remain in biochemical modeling and systems pharmacology for cell death.