Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview
Homologous Recombination02:31

Homologous Recombination

The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glutathione impacts both <i>Batrachochytrium dendrobatidis</i> virulence and amphibian cellular defence in a chytridiomycosis model.

bioRxiv : the preprint server for biology·2026
Same author

Glutathione Impacts Both Batrachochytrium dendrobatidis Virulence and Amphibian Cellular Defense in a Chytridiomycosis Model.

MicrobiologyOpen·2026
Same author

[Do chemotherapies still have a place in the era of precision medicine?]

Bulletin du cancer·2026
Same author

Using fluorescent in vitro amphibian cell infection models to quantify pathogenicity of Batrachochytrium dendrobatidis.

Methods (San Diego, Calif.)·2026
Same author

[Decoding and guidelines].

Bulletin du cancer·2026
Same author

A miRNA screen reveals a transcriptional network controlling the initiation of mammary organoids.

The FEBS journal·2026
Same journal

[ONCONNECTE À L'EMPLOI, feedback after three years of a program to prepare for returning to work after cancer in Franche-Comté].

Bulletin du cancer·2026
Same journal

[Off-label use of venetoclax in myeloma].

Bulletin du cancer·2026
Same journal

[Cemiplimab - Adjuvant treatment for the cutaneous squamous cell carcinomas with high risk of relapse, operated and treated by radiotherapy].

Bulletin du cancer·2026
Same journal

Real-world outcomes and management of endometrial cancer in France from 2016 to 2021 (MOONBEAM study).

Bulletin du cancer·2026
Same journal

[Cardiotoxicity in children and adolescents with acute leukemia: Recommendations from the Leukemia Committee of the French Society of Childhood Cancer (SFCE)].

Bulletin du cancer·2026
Same journal

[Reirradiation: A new therapeutic paradigm in oncology].

Bulletin du cancer·2026
See all related articles

Related Experiment Video

Updated: Jun 3, 2026

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
10:59

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

[General overview on DNA repair].

Philippe Pourquier1, Jacques Robert

  • 1Institut Bergonié, Université de Bordeaux, Inserm, France.

Bulletin Du Cancer
|March 19, 2011
PubMed
Summary
This summary is machine-generated.

DNA repair mechanisms fix various DNA lesions, but some anticancer drugs can overwhelm these systems. Impaired DNA repair can lead to cell death or genetic instability, potentially causing cancer.

More Related Videos

Visualization of DNA Repair Proteins Interaction by Immunofluorescence
07:55

Visualization of DNA Repair Proteins Interaction by Immunofluorescence

Published on: June 26, 2020

Visualizing Single-Stranded DNA Foci in the G1 Phase of the Cell Cycle
08:30

Visualizing Single-Stranded DNA Foci in the G1 Phase of the Cell Cycle

Published on: December 22, 2023

Related Experiment Videos

Last Updated: Jun 3, 2026

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
10:59

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

Visualization of DNA Repair Proteins Interaction by Immunofluorescence
07:55

Visualization of DNA Repair Proteins Interaction by Immunofluorescence

Published on: June 26, 2020

Visualizing Single-Stranded DNA Foci in the G1 Phase of the Cell Cycle
08:30

Visualizing Single-Stranded DNA Foci in the G1 Phase of the Cell Cycle

Published on: December 22, 2023

Area of Science:

  • Molecular biology
  • Genetics
  • Biochemistry

Context:

  • DNA is constantly subjected to damage from internal and external sources.
  • Cells possess intricate DNA repair pathways to maintain genomic integrity.
  • Dysfunctional DNA repair is implicated in various diseases, including cancer.

Purpose:

  • To provide an overview of the diverse DNA repair mechanisms.
  • To highlight the role of DNA repair in cellular response to genotoxic stress.
  • To discuss the implications of DNA repair defects in disease.

Summary:

  • DNA repair encompasses multiple pathways like mismatch repair, base excision repair, nucleotide excision repair, and double-strand break repair.
  • These pathways involve complex protein machinery to address specific DNA lesions.
  • Anticancer drugs can induce DNA damage, potentially exceeding repair capacity.

Impact:

  • Understanding DNA repair is crucial for developing novel cancer therapies.
  • Defects in DNA repair can lead to increased mutation rates and oncogenesis.
  • Targeting DNA repair pathways offers a strategy for cancer treatment.