Related Experiment Video

Updated: Jun 3, 2026

Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling
10:03

Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling

Published on: December 12, 2014

PTK7: a cell polarity receptor with multiple facets

Anne-Catherine Lhoumeau1, Francesca Puppo, Thomas Prébet

  • 1INSERM U891, Centre de Recherche en Cancérologie de Marseille, Marseille, France.

Cell Cycle (Georgetown, Tex.)
|March 19, 2011
PubMed

Insights

Protein tyrosine kinase 7 (PTK7) plays a crucial role in cell polarity and development. Our findings reveal PTK7

Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Molecular Biology

Background:

  • Planar cell polarity (PCP) is essential for tissue morphogenesis and organ development.
  • PTK7, a tyrosine kinase receptor, is known to regulate PCP.
  • Classical PCP pathways are often considered independent of beta-catenin.

Purpose of the Study:

  • To investigate the role of PTK7 in beta-catenin-dependent signaling.
  • To explore PTK7's involvement in both canonical and non-canonical Wnt pathways.
  • To understand the physiological and pathophysiological implications of PTK7 function.

Main Methods:

  • Utilizing mammalian and Xenopus model systems.
  • Analyzing genetic loss-of-function data.
  • Integrating recent experimental findings from multiple research groups.

Main Results:

  • PTK7 loss-of-function causes significant morphogenetic defects, including neural tube defects.
  • PTK7 is implicated in beta-catenin-dependent processes.
  • Evidence suggests PTK7 integrates into both canonical and non-canonical Wnt signaling.

Conclusions:

  • PTK7 is a key regulator linking PCP to beta-catenin-dependent pathways.
  • Understanding PTK7's dual role in Wnt signaling is critical for developmental processes.
  • Dysregulation of PTK7 may contribute to various pathophysiological conditions.

More Related Videos

Measuring Cell-Edge Protrusion Dynamics during Spreading using Live-Cell Microscopy05:50

Measuring Cell-Edge Protrusion Dynamics during Spreading using Live-Cell Microscopy

Published on: November 1, 2021

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors08:45

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors

Published on: July 17, 2020

Related Concept Videos

Receptor Tyrosine Kinases01:26

Receptor Tyrosine Kinases

Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
Cytoskeletal Linker Proteins - Plakins01:09

Cytoskeletal Linker Proteins - Plakins

Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...
Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...