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Related Concept Videos

Receptor Tyrosine Kinases01:26

Receptor Tyrosine Kinases

Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...
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Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
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Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...
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Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
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Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
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Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling
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Published on: December 12, 2014

PTK7: a cell polarity receptor with multiple facets.

Anne-Catherine Lhoumeau1, Francesca Puppo, Thomas Prébet

  • 1INSERM U891, Centre de Recherche en Cancérologie de Marseille, Marseille, France.

Cell Cycle (Georgetown, Tex.)
|March 19, 2011
PubMed
Summary

Protein tyrosine kinase 7 (PTK7) plays a crucial role in cell polarity and development. Our findings reveal PTK7

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Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Molecular Biology

Background:

  • Planar cell polarity (PCP) is essential for tissue morphogenesis and organ development.
  • PTK7, a tyrosine kinase receptor, is known to regulate PCP.
  • Classical PCP pathways are often considered independent of beta-catenin.

Purpose of the Study:

  • To investigate the role of PTK7 in beta-catenin-dependent signaling.
  • To explore PTK7's involvement in both canonical and non-canonical Wnt pathways.
  • To understand the physiological and pathophysiological implications of PTK7 function.

Main Methods:

  • Utilizing mammalian and Xenopus model systems.
  • Analyzing genetic loss-of-function data.
  • Integrating recent experimental findings from multiple research groups.

Main Results:

  • PTK7 loss-of-function causes significant morphogenetic defects, including neural tube defects.
  • PTK7 is implicated in beta-catenin-dependent processes.
  • Evidence suggests PTK7 integrates into both canonical and non-canonical Wnt signaling.

Conclusions:

  • PTK7 is a key regulator linking PCP to beta-catenin-dependent pathways.
  • Understanding PTK7's dual role in Wnt signaling is critical for developmental processes.
  • Dysregulation of PTK7 may contribute to various pathophysiological conditions.