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Related Experiment Video

Updated: Jun 3, 2026

Development of New Therapeutic Applications Using Microfluidics

Development of New Therapeutic Applications Using Microfluidics

Published on: October 1, 2007

2A to the fore - research, technology and applications.

Garry Luke¹, Helena Escuin, Pablo De Felipe

¹Centre for Biomolecular Sciences, School of Biology, Biomolecular Sciences Building, University of St Andrews, North Haugh, St Andrews, UK.

Biotechnology & Genetic Engineering Reviews

|March 19, 2011

Summary

The foot-and-mouth disease virus 2A region uses a unique translation mechanism to produce multiple proteins from one gene. This "2A technology" has broad applications in biotechnology and genetic engineering.

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Development of New Therapeutic Applications Using Microfluidics

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In vivo Imaging of Biological Tissues with Combined Two-Photon Fluorescence and Stimulated Raman Scattering Microscopy

In vivo Imaging of Biological Tissues with Combined Two-Photon Fluorescence and Stimulated Raman Scattering Microscopy

Published on: December 20, 2021

Area of Science:

Molecular Biology
Virology
Biotechnology

Background:

The foot-and-mouth disease virus (FMDV) 2A region possesses a unique sequence.
This sequence mediates a novel translational effect for protein processing.

Purpose of the Study:

To explain the mechanism of FMDV 2A-mediated self-processing.
To highlight the expanding applications of 2A technology.

Main Methods:

The study focuses on the translational effect of the 2A sequence.
It describes translation elongation arrest and re-initiation.

Main Results:

The 2A sequence enables the generation of discrete translation products from a single open reading frame.
2A-like sequences are present in other viruses and trypanosome retrotransposons.

Conclusions:

The 2A mechanism is a powerful tool for protein processing.
2A technology has significant biotechnological and biomedical applications, including transgenic organism creation and human embryonic stem cell manipulation.