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Updated: Jun 3, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
Neurobiology of Depression as a Comorbidity of Epilepsy
Raman Sankar1, Andrey Mazarati
1Departments of Pediatrics and Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, U.S.A.
Abstract:
The study of depression as a comorbidity of epilepsy in humans is limited by the attendant iatrogenic and psychosocial variables. In order to study the neurobiology of this clinically important phenomenon without the above-mentioned confounding factors, we have studied the behavioral and biochemical correlates of epilepsy-associated depression in two rodent models of limbic epileptogenesis. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press. Available on NCBI Bookshelf.
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