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Related Experiment Video

Updated: Jun 3, 2026

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

Heat exposure does not alter eccentric exercise-induced increases in mitochondrial calcium and respiratory

Ben Rattray¹, C Caillaud, P A Ruell

¹Exercise, Health and Performance Research Group, Faculty of Health Science, University of Sydney, Sydney, Australia. ben.rattray@canberra.edu.au

European Journal of Applied Physiology

|March 19, 2011

Summary

Intermittent heat exposure did not protect mitochondria from eccentric exercise damage. Eccentric exercise impaired mitochondrial calcium and respiration, with no benefit from heat acclimation.

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Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Published on: December 11, 2016

Area of Science:

Exercise Physiology
Mitochondrial Biology
Heat Stress Research

Background:

Eccentric exercise causes muscle damage, altering mitochondrial calcium content (MCC) and respiratory function.
Heat acclimation offers cross-tolerance to various stresses, but its mitochondrial protective effects against eccentric exercise are unknown.

Purpose of the Study:

To investigate if intermittent heat exposure protects mitochondria from eccentric exercise-induced damage.
To assess the impact of heat exposure on mitochondrial calcium handling and respiratory function post-eccentric exercise.

Main Methods:

Rats underwent 3 weeks of intermittent heat exposure (36°C) or cool conditions.
Animals performed decline treadmill exercise; mitochondrial calcium content, respiration, and mPTP opening were measured.
Measurements were taken immediately, 2h, and 48h post-exercise.

Main Results:

Heat exposure showed lower plasma creatine kinase, suggesting reduced muscle damage.
Eccentric exercise significantly increased MCC and reduced mitochondrial respiratory control ratio 48h post-exercise.
Heat exposure did not alter MCC levels or mitochondrial function following eccentric exercise.

Conclusions:

Intermittent heat exposure does not protect against mitochondrial dysfunction caused by eccentric exercise.
Eccentric exercise impairs mitochondrial respiration and calcium loading, with effects most pronounced 48h post-exercise.