Related Experiment Video

Updated: Jun 3, 2026

Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein
08:04

Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein

Published on: December 20, 2017

Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands

Brian P Dolan1, Jack R Bennink, Jonathan W Yewdell

  • 1Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA.

Cellular and Molecular Life Sciences : CMLS
|March 19, 2011
PubMed

Insights

The defective ribosomal product (DRiP) hypothesis explains how viral peptides are presented by MHC class I molecules. Recent findings suggest peptide generation involves specialized, compartmentalized translation processes.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • The defective ribosomal product (DRiP) hypothesis was proposed 15 years ago.
  • It explains the rapid presentation of viral peptides by MHC class I molecules on infected cells.

Purpose of the Study:

  • Review evidence for DRiPs in antigen processing.
  • Highlight uncertainties about the physical nature of DRiPs.
  • Emphasize recent findings on specialized peptide generation.

Main Methods:

  • Review of existing scientific literature.
  • Analysis of recent experimental findings.
  • Synthesis of evidence regarding DRiP function.

Main Results:

  • Evidence supports the contribution of DRiPs to antigen processing.
  • The exact physical nature of DRiPs remains uncertain.
  • Emerging data indicate peptide generation is a specialized process.

Conclusions:

  • DRiPs play a role in viral peptide presentation.
  • Further research is needed to clarify the nature of DRiPs.
  • Compartmentalized translation is implicated in specialized peptide generation.

More Related Videos

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes07:59

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

Related Concept Videos

Antigen Processing Pathways01:31

Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...