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Fetal pyelectasis: a possible association with Down syndrome
B R Benacerraf1, J Mandell, J A Estroff
1Department of Obstetrics and Gynecology, Brigham & Women's Hospital, Boston, Massachusetts.
Obstetrics and Gynecology
|July 1, 1990
Summary
Fetal pyelectasis, a common kidney finding, occurs in 3.3% of Down syndrome cases. This study highlights the association between renal pyelectasis and Down syndrome in prenatal screenings.
Area of Science:
- Medical Imaging
- Prenatal Diagnosis
- Genetics
Background:
- Renal pyelectasis is a frequent finding in fetal ultrasounds.
- Down syndrome is a genetic condition with various associated anomalies.
Purpose of the Study:
- To investigate the incidence of Down syndrome in fetuses with renal pyelectasis.
- To determine the prevalence of pyelectasis in fetuses diagnosed with Down syndrome.
Main Methods:
- Retrospective review of fetal ultrasound scans over a defined period.
- Analysis of kidney images in fetuses with confirmed Down syndrome.
- Calculation of incidence and prevalence rates.
Main Results:
- 210 cases of fetal renal pyelectasis were identified out of 7400 scans.
- Seven fetuses with pyelectasis also had Down syndrome.
- 25% of fetuses with Down syndrome exhibited pyelectasis; 3.3% of fetuses with pyelectasis had Down syndrome.
Conclusions:
- Fetal renal pyelectasis is associated with a higher incidence of Down syndrome.
- Prenatal screening for Down syndrome should be considered in cases of fetal pyelectasis.
- Ultrasound findings of pyelectasis may serve as a marker for genetic evaluation.