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Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors
Published on: September 10, 2013
Stimuli response of cystamine-core dendrimer revealed by diffusion and NOE NMR studies
Xueyan Feng1, Yiyun Cheng, Qinglin Wu
1CAS Key Laboratory of Soft Matter Chemistry, School of Chemistry and Material Science, University of Science and Technology of China, Hefei, Anhui, 230026, People's Republic of China.
Abstract:
Stimuli response behaviors of cystamine-core dendrimer in the presence of several reducing agents including vitamin C, sodium bisulfite, and DL-Dithiothreitol are described. A competitive redox cleavage and supramolecular aggregate formation model is proposed based on PFG NMR and (1)H NMR titration experiments. Furthermore, reduction-responsive release of guest molecules from interior pockets of the cystamine-core dendrimer is confirmed by NOE studies. The results suggest that cystamine-core dendrimer is a versatile scaffold or precursor in the design of reduction-sensitive polymeric nanocapsules for biomedical purposes.
