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Updated: Jun 3, 2026

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
Published on: March 10, 2021
Hb Phimai [β72(E16)Ser→Thr]: a novel β-globin structural variant found in association with Hb constant spring in
Sanita Singsanan1, Hataichanok Srivorakun, Goonnapa Fucharoen
1The Graduate School, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.
Abstract:
A Thai pregnant woman with α and β hemoglobinopathies is described. Initial hemoglobin (Hb) analysis revealed an unknown variant with a high performance liquid chromatography (HPLC) elution pattern similar to Hb Hope [β136(H14)Gly→Asp]. Subsequent DNA-based diagnostics revealed that she was a carrier of Hb Constant Spring [Hb CS, α142, TAA>CAA (α2)] and a novel β-globin chain variant [β72(E16)Ser→Thr, AGT>ACT] which we named Hb Phimai. Her hematological findings and a simple DNA test for differential diagnosis of Hb Phimai and Hb Hope are presented.
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