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Coulometry: Overview01:00

Coulometry: Overview

Coulometry is one of the rapid, most accurate, and precise analytical techniques that determine the quantity of an analyte by measuring the electrical charge needed for its complete electrolysis without using any analytical standards. The total charge passed during electrolysis correlates with the analyte amount by Faraday's laws of electrolysis. For accurate coulometric measurements, a charge equal to Faraday's constant multiplied by the number of electrons involved in the relevant...
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Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
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Health Information Technology (HIT)
Health Information Technology, commonly called HIT, integrates advanced information systems and technology in healthcare settings. Its primary functions include:

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Technology evaluation: Kollicoat IR.

Ehab A Fouad1, Mahmoud El-Badry, Steven H Neau

  • 1King Saud University, College of Pharmacy, Department of Pharmaceutics, PO Box 2457, Riyadh 11451, Saudi Arabia.

Expert Opinion on Drug Delivery
|March 23, 2011
PubMed
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Kollicoat IR, a versatile pharmaceutical excipient, offers broad applications beyond immediate-release coatings. Its unique properties enable controlled drug release and improved solid dispersions for poorly soluble drugs.

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Area of Science:

  • Pharmaceutical excipients
  • Polymer science
  • Drug delivery systems

Background:

  • Kollicoat IR is a recently introduced excipient with existing applications beyond immediate-release coatings.
  • Industrial pharmacy advancements are often driven by the discovery of novel pharmaceutical excipients.

Purpose of the Study:

  • To review the properties and pharmaceutical applications of Kollicoat IR as an excipient.
  • To examine the chemical structure and physicochemical characteristics of Kollicoat IR.
  • To present available Kollicoat IR products and preclinical studies for its use in instant release coatings.

Main Methods:

  • Review of chemical structure and physicochemical properties.
  • Presentation of available Kollicoat IR products.
  • Overview of preclinical studies for instant release coating applications.

Main Results:

  • Kollicoat IR's physicochemical properties, derived from grafting PEG with polyvinyl alcohol, lead to diverse applications.
  • Incorporation of Kollicoat IR into ethylcellulose or polyvinyl acetate coatings successfully modified drug release rates.
  • Kollicoat IR facilitates the creation of fast-dissolving solid dispersions with poorly soluble drugs via hot stage extrusion, spray drying, or freeze drying.

Conclusions:

  • Kollicoat IR's properties support its use in controlled-release formulations and solid dispersions.
  • Understanding Kollicoat IR's characteristics can unlock new pharmaceutical applications.
  • The excipient shows promise for enhancing drug solubility and modifying drug release profiles.