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The Establishment of a Murine Maxillary Orthodontic Model
Published on: October 27, 2023
Tooth-bone morphogenesis during postnatal stages of mouse first molar development.
Vlasta Lungová1, Ralf J Radlanski, Abigail S Tucker
1Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
Journal of Anatomy
|March 23, 2011
Summary
This study details the postnatal development of the first mouse molar (M1), revealing key cellular processes like proliferation and apoptosis that drive tooth formation and root anchoring. It highlights the dynamic interplay between tooth development and jawbone remodeling.
Area of Science:
- Developmental Biology
- Craniofacial Development
- Odontogenesis
Background:
- Research on tooth development (odontogenesis) often focuses on prenatal stages.
- Postnatal development is crucial for functional dentition, root formation, and jaw anchoring.
- The first mouse molar (M1) serves as a key model for studying these processes.
Purpose of the Study:
- To investigate the postnatal morphogenesis of the M1 from birth to eruption.
- To analyze cell proliferation and apoptosis during M1 development.
- To correlate tooth development with the remodeling of surrounding jawbone tissue.
Main Methods:
- Studied M1 development from postnatal day 0 to eruption (around P20).
- Assessed tooth morphogenesis, cell proliferation, and apoptosis.
- Utilized three-dimensional reconstruction to visualize tooth and bone development.
- Correlated cellular events with jawbone remodeling.
Main Results:
- Crown formation completed by postnatal days 0-2; root development initiated at P4.
- Cell proliferation in dental epithelium decreased and shifted apically (P2-P12), while dental follicle mesenchymal cell proliferation increased.
- Cell proliferation ceased before eruption (P20), coinciding with mineralization and differentiation.
- Apoptosis occurred throughout development, aiding in cell removal and bone remodeling.
- Alveolar crypts formed via resorption; interdental ridges formed by bone growth.
Conclusions:
- Postnatal M1 development involves dynamic shifts in cell proliferation and programmed cell death (apoptosis).
- Apoptosis plays a significant role in both tooth morphogenesis and the remodeling of the supporting alveolar bone.
- The coordinated processes of tooth growth and bone remodeling establish the functional dentition and its integration into the jaw.
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