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Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
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Published on: December 27, 2017

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Hematopoietic stromal cells and megakaryocyte development

Yimei Feng1, Lei Gao, Xinghua Chen

  • 1Department of Hematology, Second Affiliated Hospital, Third Military Medical University, Chongqing, China.

Hematology (Amsterdam, Netherlands)
|March 23, 2011
PubMed

The hematopoietic microenvironment, and in particular the hematopoietic stromal cell element, are intimately involved in megakaryocyte development. The process of megakaryocytopoiesis occurs within a complex bone marrow microenvironment where adhesive interactions, chemokines, as well as cytokines play a pivotal role. Here we review the effect of stromal cells and cytokines on megakaryocytopoiesis with the aim of exploring new therapeutic strategies for platelet recovery after hematopoietic stem cell transplantation (HSCT).

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