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Updated: Jun 3, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
Romiplostin may revert the thrombocytopenia in graft-versus-host disease
Guillermo J Ruiz-Delgado1, Julia Lutz-Presno, Guillermo J Ruiz-Argüelles
1Laboratorios Clínicos de Puebla, Mexico.
Abstract:
The thrombocytopenia ensuing during acute graft-versus-host disease (GVHD) is multifactorial and may significantly compromise the prognosis of the patient; non-immune persistent thrombocytopenia has been considered as an adverse prognostic factor in GVHD. We describe here the case of a 10-year-old girl who developed steroid-refractory thrombocytopenia and who responded promptly to the subcutaneous delivery of romiplostin. To the best of our knowledge, this is the first description of the usefulness of the peptibody in the setting of GVHD.
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