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Enhancing Tumor Content through Tumor Macrodissection
Published on: February 12, 2022
Diffuse large B-cell lymphoma primary of lung.
Natividad Neri1, M Jesús Nambo, Agustin Avilés
1Department of Hematology, Oncology Hospital, National Medical Center, IMSS, México, DF, Mexico.
Hematology (Amsterdam, Netherlands)
|March 23, 2011
Summary
Primary lung lymphoma (PLL) is a rare diffuse large B-cell lymphoma (DLBCL) with a good prognosis. This study of 82 cases treated with CHOP chemotherapy found high survival rates, with no significant difference based on cell of origin.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Primary lung lymphoma (PLL) and diffuse large B-cell lymphoma (DLBCL) are rare, with poorly defined characteristics.
- Limited data exists on prognosis markers and optimal treatment for PLL-DLBCL.
Purpose of the Study:
- To analyze a large cohort of PLL-DLBCL patients treated with conventional chemotherapy.
- To investigate the prognostic significance of cell of origin (germinal center vs. non-germinal center) in PLL-DLBCL.
Main Methods:
- Retrospective analysis of 82 patients with early-stage, low-risk PLL-DLBCL.
- Treatment with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy.
- Immunohistochemical studies to determine germinal center (GC) and non-GC phenotypes.
Main Results:
- Complete response achieved in 94% of patients.
- 10-year event-free survival (EFS) was 90% and overall survival (OS) was 92%.
- No statistically significant difference in response, EFS, or OS between GC (n=59) and non-GC (n=23) phenotypes.
Conclusions:
- PLL-DLBCL is an extranodal lymphoma with a favorable prognosis.
- Conventional CHOP chemotherapy is effective and well-tolerated.
- Cell of origin does not appear to significantly impact prognosis in this cohort.
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