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Related Experiment Video

Updated: Jun 3, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Structural brain abnormalities common to posttraumatic stress disorder and depression.

Marijn C W Kroes¹, Michael D Rugg, Matthew G Whalley

¹Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, the Netherlands.

Journal of Psychiatry & Neuroscience : JPN

|March 23, 2011

Summary

Brain volume reductions in prefrontal areas are common in posttraumatic stress disorder (PTSD) and major depression. Subtle differences emerged correlating psychopathology severity with specific brain structures.

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Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

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Area of Science:

Neuroscience
Psychiatry
Neuroimaging

Background:

Posttraumatic stress disorder (PTSD) and major depression share similar brain volume reductions.
Previous volumetric studies have not directly contrasted these conditions.
This study investigates unique grey matter reductions in each disorder.

Purpose of the Study:

To identify grey matter volume differences between PTSD and major depression.
To explore correlations between brain volume and psychopathology severity.

Main Methods:

Structural MRI scans were acquired from participants with PTSD, major depression, and controls.
Voxel-based morphometry with the DARTEL algorithm (SPM5) was used for volumetric analysis.
Standardized self-report measures of anxiety and depression were administered.

Main Results:

PTSD and major depression groups showed reduced brain volumes compared to controls, particularly in prefrontal areas.
No significant differences in grey matter volume were found between the PTSD and major depression groups.
Anxiety and depression severity correlated with distinct brain volume patterns in each disorder.

Conclusions:

Shared prefrontal grey matter reductions in PTSD and major depression suggest these findings are not disorder-specific.
Distinct structural correlates of self-reported anxiety and depression highlight subtle differences between the conditions.