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Updated: Jun 3, 2026
Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
[Histopathologic analysis of 1500 renal allograft biopsies]
Hui Guo1, Zheng-bin Lin, Wei-jie Zhang
1Institute of Organ Transplantation, Key Lab on Transplantation of Ministry of Education and Ministry of Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
Objective:
To summarize the histopathological features of posttransplant complications for renal allografts and evaluate the biopsy values.
Methods:
Between January 1997 and May 2010, a total of 1712 percutaneous renal allograft biopsies were performed in 1500 kidney transplants and diagnostic procedures for staining, classification and staging had been performed according to the Banff 1997 and 2005 Schema.
Results:
There were 213 (14.2%) cases of acute T cell-mediated rejection post transplantation in 1500 kidney transplants. Meanwhile there were 36 (2.4%) cases of acute antibody-mediated rejection. Chronic T cell-mediated rejection and chronic antibody-mediated rejection were 251 (16.7%) cases and 45 (3.0%) cases, respectively. Acute CNI-nephrotoxicity and chronic CNI-nephrotoxicity were 106 (7.1%)cases and 251 (16.7%) cases, respectively. Relapsed or new nephropathy were 6 (0.4%) cases. Chronic CNI-nephrotoxicity is the most common cause of allograft dysfunction in the long survival recipients.
Conclusion:
Percutaneous renal allograft biopsy is valuable for the diagnosis of various posttransplantation complications.
