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Immunomodulatory therapy of cancer with T cell-engaging BiTE antibody blinatumomab

Dirk Nagorsen1, Patrick A Baeuerle

  • 1Micromet, Inc, 6707 Democracy Blvd, Bethesda, MD 20817, USA. dirk.nagorsen@micromet.com

Experimental Cell Research
|March 23, 2011
PubMed

Severe side effects and few long-term remissions frequently limit the treatment of advanced malignant diseases. Bispecific antibodies are currently emerging as a new option for the treatment of malignant diseases, which can potentially engage all cytotoxic T cells of a patient for tumor cell lysis. Blinatumomab, a bispecific single-chain BiTE antibody construct with dual specificity for CD19 and CD3, is a front runner of this antibody class. We here summarize the current state of development of blinatumomab for the treatment of patients with B-cell non-Hodgkin's lymphoma (NHL) and B-precursor acute lymphocytic leukemia (ALL). High response rates and durable remissions are observed in first clinical trials, indicating that T cells can be potently redirected for efficient and lasting elimination of malignant cells.

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