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Related Experiment Video

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Published on: July 28, 2013

Microscopic diffusion tensor atlas of the mouse brain.

Yi Jiang1, G Allan Johnson

  • 1Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC 27710, USA.

Neuroimage
|March 23, 2011
PubMed
Summary

This study presents high-resolution diffusion tensor imaging (DTI) of mouse brains, establishing a reliable method for analyzing white matter structures and creating a valuable resource for neuroinformatics research.

Area of Science:

  • Neuroimaging
  • Biomedical Engineering
  • Neuroscience

Background:

  • Diffusion Tensor Imaging (DTI) is crucial for mapping white matter tracts.
  • Accurate registration to a common reference space is essential for comparative neuroimaging studies.
  • The Waxholm Space provides a standardized atlas for mouse brain research.

Purpose of the Study:

  • To establish a high-resolution DTI dataset of normal adult C57BL/6J mouse brains.
  • To develop and validate a robust registration protocol to Waxholm Space.
  • To generate DTI atlases and assess data consistency for future research.

Main Methods:

  • Acquired eight DTI datasets at 43-micrometer resolution.
  • Used T1- and T2*-weighted images for nonlinear registration to Waxholm Space.

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  • Identified 80 landmarks to quantify registration accuracy, achieving <130 micrometers for 95% of landmarks.

    • Main Results:

    • Registration accuracy was high (65±40 micrometers overall landmark displacement).
    • Generated mean and coefficient of variation atlases for DTI indices.
    • Demonstrated high consistency of DTI data across subjects and significant differences between white matter structures.

    Conclusions:

    • The developed DTI protocol provides consistent and reproducible data.
    • The high-resolution datasets and atlases are a valuable addition to the Waxholm Space.
    • This resource facilitates voxel-based and region-of-interest analyses in mouse brain research.