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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...

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Related Experiment Video

Updated: Jun 3, 2026

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
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DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

L-Carnitine and intestinal inflammation.

Geneviève Fortin1

  • 1Department of Experimental Medicine, McGill University, Montreal, Quebec, Canada.

Vitamins and Hormones
|March 23, 2011
PubMed
Summary

L-carnitine supplementation shows promise for intestinal inflammation by improving the epithelial barrier and reducing oxidative stress. Research also links l-carnitine transporter gene mutations to Crohn's disease.

Area of Science:

  • Gastroenterology
  • Immunology
  • Cell Biology

Background:

  • The intestinal barrier is a dynamic interface between the host immune system and luminal contents.
  • Epithelial barrier integrity, oxidative stress, and immune cell activation are critical in intestinal health.

Purpose of the Study:

  • To review the evidence for l-carnitine's impact on intestinal barrier function, oxidative stress, and immune responses.
  • To explore the therapeutic potential of l-carnitine supplementation for intestinal inflammation.
  • To examine the association between Crohn's disease and l-carnitine transporter gene mutations.

Main Methods:

  • Literature review of studies investigating l-carnitine's effects on intestinal health markers.
  • Analysis of functional data related to l-carnitine transporter genes and Crohn's disease.

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Main Results:

  • L-carnitine positively influences epithelial barrier integrity and modulates oxidative stress.
  • Evidence suggests l-carnitine supplementation may benefit conditions involving intestinal inflammation.
  • Genetic data indicate a potential link between l-carnitine transporter gene mutations and Crohn's disease.

Conclusions:

  • L-carnitine demonstrates therapeutic potential for intestinal inflammation due to its beneficial effects on key factors.
  • The safety profile of l-carnitine supports its consideration for supplementation.
  • Further research into the role of l-carnitine and its transporters in inflammatory bowel diseases is warranted.