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Related Experiment Videos

Morphometry of the aging heart.

T R Burns1, M Klima, T A Teasdale

  • 1Department of Pathology, Veterans Administration Medical Center, Houston, Texas.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
|May 1, 1990
PubMed
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Aging hearts show increased interstitial collagen in the posterior left ventricle and midmyocardial myocyte hypertrophy. Elderly hearts also exhibit shrinking myocyte nuclei in the subepicardial zone, indicating age-related myocardial structural changes.

Area of Science:

  • Cardiovascular Biology
  • Geriatric Medicine
  • Cardiac Pathology

Background:

  • Aging is associated with changes in myocardial structure and function.
  • Understanding age-related alterations in the heart is crucial for geriatric cardiovascular health.

Purpose of the Study:

  • To investigate age-related changes in myocardial structure, including interstitial collagen content and myocyte dimensions.
  • To compare these changes between geriatric and younger adult hearts across different cardiac regions and zones.

Main Methods:

  • Computerized morphometry was used to analyze myocardial sections from geriatric and younger adult hearts.
  • Interstitial collagen content, myocyte nuclear, and cell diameters were quantified in subepicardial, midmyocardial, and subendocardial zones of the posterior left ventricle, anterior left ventricle, and ventricular septum.

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  • Student's t-test was employed for statistical analysis with significance set at P < 0.001.

    • Main Results:

    • Elderly hearts exhibited significantly increased interstitial collagen in the posterior left ventricle (18.3%) compared to younger hearts (6.61%) (P < 0.001).
    • Relative myocyte hypertrophy was most prominent in the midmyocardial zone of elderly hearts (P < 0.001).
    • Myocyte nuclei showed significant shrinking with age in the subepicardial zone (P < 0.001).

    Conclusions:

    • Aging leads to specific structural alterations in the myocardium, including increased interstitial fibrosis and myocyte hypertrophy.
    • These age-related changes, particularly in the posterior left ventricle and midmyocardium, may contribute to functional impairments observed in the elderly.
    • The study highlights regional and zonal differences in myocardial aging.