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Related Concept Videos

Cellular Injury V: Apoptosis and Autophagy01:22

Cellular Injury V: Apoptosis and Autophagy

Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...
Autophagic Cell Death01:18

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
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Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...
Autophagy01:27

Autophagy

Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
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DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

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Overview of DNA Repair02:25

Overview of DNA Repair

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Related Experiment Video

Updated: Jun 3, 2026

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
10:59

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

DNA damage and autophagy.

Humberto Rodriguez-Rocha1, Aracely Garcia-Garcia, Mihalis I Panayiotidis

  • 1Redox Biology Center and School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, United States.

Mutation Research
|March 23, 2011
PubMed
Summary
This summary is machine-generated.

DNA damage from environmental or metabolic factors can cause disease. This review explores how autophagy, a cellular recycling process, may be a key part of the DNA damage response.

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Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Genetics

Background:

  • DNA integrity is crucial for preventing human disorders like cancer and neurodegenerative diseases.
  • DNA damage can arise from exogenous sources (UV radiation, chemicals) and endogenous sources (metabolic byproducts).
  • Cellular mechanisms exist to detect, signal, and repair DNA lesions, but unrepaired damage can lead to cell death or senescence.

Purpose of the Study:

  • To review the evidence supporting a role for autophagy in the DNA damage response.
  • To elucidate the mechanisms by which DNA damage induces autophagy.
  • To understand the significance of autophagy in determining cellular fate following DNA damage.

Main Methods:

  • Literature review of existing research on DNA damage, DNA damage response, and autophagy.
  • Analysis of studies investigating the interplay between DNA damage signaling pathways and autophagic processes.
  • Synthesis of evidence from various experimental models to support or refute the proposed role of autophagy.

Main Results:

  • DNA damage has been observed to induce autophagy, a cellular catabolic process.
  • The precise molecular mechanisms linking DNA damage to autophagy induction are still under investigation.
  • The exact role and implications of autophagy in the context of DNA damage response and cellular fate remain largely unknown.

Conclusions:

  • Autophagy is increasingly recognized as an integral component of the cellular response to DNA damage.
  • Further research is needed to fully understand the mechanisms and functional significance of autophagy in DNA repair and cell fate decisions.
  • Investigating autophagy's role could reveal new therapeutic strategies for diseases associated with DNA damage.