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Related Concept Videos

Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Oogenesis01:22

Oogenesis

Oogenesis,  the process of developing egg cells (female gametes), occurs within the ovaries and is fundamental to female fertility. This sequence begins during fetal development when diploid oogonia in the developing ovaries undergo mitotic divisions to produce primary oocytes. By birth, these primary oocytes enter prophase I of meiosis but become arrested in this stage, remaining suspended until puberty.
Each primary oocyte is surrounded by a layer of pre-granulosa cells, forming what is known...
Folliculogenesis01:20

Folliculogenesis

Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
Ovarian Cycle01:27

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...
Ovaries01:26

Ovaries

The ovaries are roughly the size of almonds and measure approximately 2 to 3 centimeters in length. These paired structures are situated within the pelvic region and are anchored by the mesovarium—a peritoneal extension that also connects them to the wider structure of the broad ligament. The support system extends to the suspensory ligament, housing blood and lymphatic vessels. In addition, the ovarian ligament tethers the ovaries to the uterus.
On the ovarian surface, a layer of cuboidal...
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...

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Related Experiment Video

Updated: Jun 3, 2026

In Situ Labeling of Mitochondrial DNA Replication in Drosophila Adult Ovaries by EdU Staining
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In Situ Labeling of Mitochondrial DNA Replication in Drosophila Adult Ovaries by EdU Staining

Published on: October 15, 2016

Oogenesis: matrix revolutions.

Rebecca Bastock1, Daniel St Johnston

  • 1The Gurdon Institute and the Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

Current Biology : CB
|March 23, 2011
PubMed
Summary

Drosophila egg chambers elongate by spinning and depositing an extracellular matrix. This matrix acts as a molecular corset, preventing the egg chambers from expanding outwards.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Genetics

Background:

  • The process of egg-chamber elongation in Drosophila oogenesis remains poorly understood.
  • Investigating the cellular and molecular mechanisms driving developmental processes is crucial for understanding organismal development.

Purpose of the Study:

  • To elucidate the mechanism behind egg-chamber elongation during Drosophila oogenesis.
  • To identify the role of extracellular matrix in regulating egg chamber morphology.

Main Methods:

  • Live imaging of Drosophila egg chambers.
  • Analysis of extracellular matrix deposition and organization.
  • Genetic manipulation to study the function of ECM components.

Main Results:

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Production and Use of Customizable Agarose Molds for Scaffold-Free Mouse Ovarian Follicle Culture

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Nuclear Migration in the Drosophila Oocyte
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Nuclear Migration in the Drosophila Oocyte

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Last Updated: Jun 3, 2026

In Situ Labeling of Mitochondrial DNA Replication in Drosophila Adult Ovaries by EdU Staining
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Nuclear Migration in the Drosophila Oocyte
04:17

Nuclear Migration in the Drosophila Oocyte

Published on: May 13, 2021

  • Drosophila egg chambers exhibit rotational movement along their long axis.
  • Polarized extracellular matrix is deposited during this rotation.
  • The deposited extracellular matrix restricts radial expansion, guiding elongation.

Conclusions:

  • The rotational movement and polarized ECM deposition are key to Drosophila egg-chamber elongation.
  • The extracellular matrix functions as a molecular corset, controlling egg chamber shape.
  • This mechanism provides a novel insight into morphogenetic processes in developmental biology.