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Related Concept Videos

Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...

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Related Experiment Video

Updated: Jun 3, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Tuberculosis.

Stephen D Lawn1, Alimuddin I Zumla

  • 1The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.

Lancet (London, England)
|March 23, 2011
PubMed
Summary

Tuberculosis remains a global health crisis, causing millions of deaths annually. Urgent investment and political commitment are vital for developing new diagnostics, drugs, and vaccines to combat this persistent infectious disease.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Epidemiology

Background:

  • Tuberculosis (TB) causes over 1.7 million deaths and 9 million new cases yearly, disproportionately affecting low- and middle-income countries.
  • HIV significantly increases TB susceptibility, particularly in sub-Saharan Africa, where four out of five HIV-associated TB cases occur.
  • Current TB diagnostics (sputum microscopy) and treatments are inadequate, facing challenges from drug resistance and protracted regimens.

Purpose of the Study:

  • To present current perspectives on the global tuberculosis epidemic.
  • To review the pathogen, host response, and emerging control methods for tuberculosis.
  • To highlight the ongoing challenges in tuberculosis control in the 21st century.

Main Methods:

  • Review of current scientific literature and research on tuberculosis.

Related Experiment Videos

Last Updated: Jun 3, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

  • Analysis of epidemiological data on tuberculosis incidence, mortality, and drug resistance.
  • Synthesis of information on diagnostics, biomarkers, drugs, and vaccines for tuberculosis.

    • Main Results:

    • Significant progress in basic science and translational research has yielded promising developments in TB diagnostics, biomarkers, drugs, and vaccines.
    • Increasing rates of drug-resistant tuberculosis threaten global control efforts.
    • Fundamental understanding of tuberculosis pathogenesis remains inadequate.

    Conclusions:

    • Despite progress, tuberculosis remains a major global public health challenge requiring increased investment and political commitment.
    • New diagnostics, effective drugs, and vaccines are crucial for controlling the tuberculosis epidemic.
    • Addressing the multifaceted challenges of tuberculosis control necessitates a comprehensive and sustained global effort.