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Bacterial pathogens depend on precise and efficient DNA replication to sustain infection. Two type II topoisomerases—DNA gyrase and topoisomerase IV—are critical to this process, as they resolve DNA supercoiling and unlink chromosomes during replication. Fluoroquinolones, synthetic derivatives of quinolones, exploit this mechanism by stabilizing the transient DNA–enzyme cleavage complex, preventing strand religation, and causing lethal double-strand breaks. These antibiotics are selectively...
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Ceftaroline: a comprehensive update.

Darpan Kaushik1, Sudeep Rathi, Ankit Jain

  • 1Department of Pharmaceutical Chemistry, Rajendra Institute of Technology & Sciences, 4th Mile Stone, Hisar Road, Sirsa 125055, Haryana, India. darpkaush@yahoo.com

International Journal of Antimicrobial Agents
|March 23, 2011
PubMed
Summary
This summary is machine-generated.

Ceftaroline is a new cephalosporin antibiotic effective against resistant bacteria, including MRSA. It shows promise for treating skin infections and pneumonia, with a good safety profile.

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Area of Science:

  • Pharmacology
  • Infectious Diseases

Background:

  • Ceftaroline is a novel broad-spectrum cephalosporin antibiotic.
  • It is under FDA review for treating complicated skin infections (cSSSIs) and community-associated pneumonia (CAP).

Purpose of the Study:

  • To evaluate the efficacy and safety of ceftaroline for treating cSSSIs and CAP.

Main Methods:

  • Ceftaroline acts by binding to penicillin-binding proteins, similar to other beta-lactams.
  • Its spectrum includes Gram-positive bacteria (like resistant Staphylococcus aureus) and Gram-negative pathogens.
  • Ceftaroline fosamil is a prodrug rapidly converted to active ceftaroline in vivo.

Main Results:

  • Ceftaroline demonstrates broad antimicrobial activity against various resistant pathogens.
  • Pharmacokinetic studies show a two-compartmental model and renal excretion, with a half-life of approximately 2.5 hours.
  • Clinical trials indicate ceftaroline is well tolerated, with a safety profile comparable to other cephalosporins.

Conclusions:

  • Ceftaroline is a promising antibiotic for combating multidrug-resistant bacteria, including S. aureus and Streptococcus pneumoniae.
  • It offers a potential new treatment option for cSSSIs and CAP.