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Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
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CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its effects by...
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Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

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Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

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Local Anesthetics: Common Agents and Their Applications

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Related Experiment Video

Updated: Jun 3, 2026

Organotypic Hippocampal Slice Cultures As a Model to Study Neuroprotection and Invasiveness of Tumor Cells
07:48

Organotypic Hippocampal Slice Cultures As a Model to Study Neuroprotection and Invasiveness of Tumor Cells

Published on: August 27, 2017

Neuroprotective agents: cannabinoids.

A J Sánchez1, A García-Merino

  • 1Neuroimmunology Laboratory and Neurology Service, Hospital Universitario Puerta de Hierro, Majadahonda,Universidad Autónoma de Madrid, Madrid, Spain.

Clinical Immunology (Orlando, Fla.)
|March 23, 2011
PubMed
Summary
This summary is machine-generated.

Cannabinoids show promise for multiple sclerosis (MS) by reducing inflammation and protecting nerve cells. Research suggests they can modulate immune cells and offer neuroprotection, potentially slowing MS progression.

Related Experiment Videos

Last Updated: Jun 3, 2026

Organotypic Hippocampal Slice Cultures As a Model to Study Neuroprotection and Invasiveness of Tumor Cells
07:48

Organotypic Hippocampal Slice Cultures As a Model to Study Neuroprotection and Invasiveness of Tumor Cells

Published on: August 27, 2017

Area of Science:

  • Neuroimmunology
  • Neuropharmacology

Background:

  • Multiple sclerosis (MS) is characterized by chronic inflammation and neurodegeneration.
  • Current MS treatments manage inflammation but do not halt disease progression.
  • The endocannabinoid system is implicated and often disturbed in MS.

Purpose of the Study:

  • To explore the potential of cannabinoids as therapeutic agents for multiple sclerosis.
  • To review the immunomodulatory and neuroprotective effects of cannabinoids in MS models.

Main Methods:

  • Review of experimental studies on cannabinoids in animal models of MS.
  • Analysis of cannabinoid receptor (CB1 and CB2) mechanisms of action.

Main Results:

  • Cannabinoids exhibit immunomodulatory effects via CB2 receptor activation, impacting lymphocytes and microglia.
  • Cannabinoids provide neuroprotection through CB1 receptor activation, particularly against excitotoxicity.
  • Evidence suggests cannabinoids can interfere with immune cell migration across the blood-brain barrier.

Conclusions:

  • Cannabinoids possess demonstrated immunomodulatory and neuroprotective properties relevant to MS.
  • Targeting the endocannabinoid system with cannabinoids may offer a novel therapeutic strategy for MS.
  • Further research into cannabinoids could address unmet needs in managing MS progression.