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[Pathogenesis of the climacteric syndrome]
1The Fourth Military Medical University, Xi'an.
Zhonghua Fu Chan Ke Za Zhi
|March 1, 1990
Summary
Menopausal syndrome involves abnormal nailfold microcirculation and nervous system function. Lower serotonin and beta-endorphin levels in patients suggest a link to these physiological changes.
Area of Science:
- Endocrinology
- Neuroscience
- Physiology
Context:
- Climacteric syndrome, commonly known as menopause, affects numerous women.
- Understanding the underlying pathogenesis is crucial for effective management.
- Previous research has indicated various physiological changes during this period.
Purpose:
- To investigate the pathogenesis of climacteric syndrome.
- To explore the relationship between neuroendocrine factors and physiological changes.
Summary:
- Abnormal nailfold microcirculation and vegetative nervous system function were observed in 79 patients.
- Blood serotonin levels were significantly lower in 10 oophorectomized women compared to controls.
- Plasma beta-endorphin and anti-beta-endorphin antibody concentrations were reduced in patients with climacteric syndrome.
Impact:
- Findings suggest that alterations in serotonin and beta-endorphin may contribute to the clinical manifestations of menopause.
- These neuroendocrine changes appear linked to autonomic nervous system dysfunction and microcirculatory abnormalities.
- This research provides insights into the complex pathophysiology of menopausal symptoms.