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Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
Published on: April 24, 2020
[Intracranial hypertension and lupus]
E Maillart1, A Gueguen, M Obadia
1Service de Neurologie, Fondation Ophtalmologique A-de-Rothschild, 25-29 rue Manin, 75940 Paris cedex 9, France. emaillart@fo-rothschild.fr
Revue Neurologique
|March 23, 2011
Summary
Idiopathic intracranial hypertension (IH) can be associated with systemic lupus erythematosus (SLE), particularly in young women with nephritis. Early diagnosis and treatment are crucial for managing this rare complication.
Area of Science:
- Neurology
- Nephrology
- Rheumatology
Background:
- Idiopathic intracranial hypertension (IH) is more prevalent in women and overweight individuals.
- Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that can present with various organ involvements.
- A potential association between IH and SLE, especially with nephritis, has been noted in medical literature.
Observation:
- A case of a 29-year-old woman with SLE, skin and arthritic manifestations, and subsequent glomerulonephritis is presented.
- The patient developed IH with papilledema six weeks after the onset of nephrotic syndrome, despite immunosuppressive therapy.
- Cerebral imaging and cerebrospinal fluid analysis ruled out cerebral venous thrombosis and other abnormalities, confirming IH.
Findings:
- Twenty-seven cases of IH associated with SLE and nephritis have been documented.
- Young women are disproportionately affected, often with diffuse proliferative glomerulonephritis.
- Factors like anemia may contribute to the development of IH in SLE patients.
Implications:
- SLE should be investigated as a potential cause of IH, especially in non-obese patients presenting with nephritis.
- IH can sometimes be an early indicator for diagnosing SLE.
- Prompt management, including cerebrospinal fluid evacuation and adjusted immunosuppression, can lead to symptom resolution.
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