New insights into the function of transcription factor TFIID from recent structural studies

Gabor Papai1, P Anthony Weil, Patrick Schultz

  • 1Integrated Structural Biology Department, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), U964 Inserm, UMR7104 CNRS-Université de Strasbourg, 1 rue Laurent Fries, BP10142, 67404 Illkirch, France.

Abstract

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
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