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Primate lens capsule elasticity assessed using Atomic Force Microscopy.

Noël M Ziebarth1, Esdras Arrieta, William J Feuer

  • 1Department of Biomedical Engineering, University of Miami, College of Engineering, 1251 Memorial Drive, McArthur Annex Room 209, Coral Gables, FL 33146, USA. nziebarth@miami.edu

Experimental Eye Research
|March 23, 2011
PubMed
Summary
This summary is machine-generated.

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The elasticity of human and primate lens capsules was measured using Atomic Force Microscopy (AFM). Human lens capsule stiffness increases with age, while young humans

Area of Science:

  • Ophthalmic biomechanics
  • Biomaterials science
  • Cell biology

Background:

  • The lens capsule's mechanical properties are crucial for maintaining lens shape and function.
  • Age-related changes in the lens capsule's elasticity may contribute to presbyopia and other visual impairments.
  • Understanding the microscale elasticity is essential for developing effective treatments for age-related vision changes.

Purpose of the Study:

  • To quantitatively measure the microscopic elasticity of human and non-human primate lens capsules.
  • To investigate the relationship between age and lens capsule elasticity in humans and primates.
  • To compare the elasticity of human and non-human primate lens capsules.

Main Methods:

  • Excised anterior lens capsules from human, cynomolgus monkey, and hamadryas baboon eyes were used.

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  • Lens epithelial cells were removed using trypsin and EDTA treatment.
  • Atomic Force Microscopy (AFM) with a custom-built system was employed to obtain force-indentation curves.
  • Young's modulus was calculated using Sneddon's model for conical indentation.

    • Main Results:

    • Young's modulus of elasticity for human lens capsule ranged from 20.1-131 kPa.
    • Young's modulus for cynomolgus monkey lens capsule ranged from 9.19-117 kPa.
    • Young's modulus for baboon lens capsule ranged from 13.1-62.4 kPa.
    • Human lens capsule elasticity significantly increased with age (p=0.03).
    • The elasticity of young human (<45 years) and primate lens capsules were not statistically different.
    • Human lens capsule elasticity increased at the microscale, potentially contributing to bulk stiffness.

    Conclusions:

    • Human lens capsule elasticity increases with age, suggesting a role in age-related changes in lens function.
    • Microscale elasticity measurements provide valuable insights into the biomechanical properties of the lens capsule.
    • Primate lens capsules serve as a relevant model for studying human lens capsule biomechanics, particularly in younger age groups.