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[Effect of short-term intensive therapy with glimepiride and metformin in newly diagnosed type 2 diabetic patients]
Min WANG1, Fang GAO, Yao-ming XUE
1Department of Endocrinology and Tuberculosis, Guangzhou Chest Hospital, Guangzhou 510095, China. gfmhx96@fimmu.com
Objective:
To evaluate the effect of short-term intensive therapy on blood glucose control, BETA-cell function, and blood lipid levels in newly diagnosed type 2 diabetic patients.
Methods:
Out-patients with newly diagnosed type 2 diabetic patients were enrolled for intensive treatment with sulfonylureas and metformin for 12 weeks, and the therapeutic effect was evaluated.
Results:
After the intensive treatment, FPG, 2 hPG, and HbA1c decreased significantly (P<0.01); HOMA-IR decreased and HOMA-B increased significantly (P<0.01), and TG, CHOL, LDL decreased significantly (P<0.01) after the treatment.
Conclusion:
Short-term intensive treatment with glimepiride combined with metformin is safe and effective in newly diagnosed type 2 diabetic patients with HbA1c>9%.
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