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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

[A relationship between CRP, adiponectin and Gensini score in the patients with coronary artery disease]

Dursun Dursunoğlu1, Hidayet Göksoy, Mehmet Oztürk

  • 1Pamukkale Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dali, Denizli, Türkiye. dursundursunoglu@yahoo.com

Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology
|March 23, 2011
PubMed

Insights

Coronary artery disease (CAD) patients show lower adiponectin and higher C-reactive protein (CRP) levels compared to controls. Both CRP and adiponectin levels correlate with the severity of coronary lesions, as indicated by the Gensini score.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation

Background:

  • Coronary artery disease (CAD) is a leading cause of mortality worldwide.
  • Inflammation plays a crucial role in the pathogenesis of atherosclerosis.
  • Adiponectin and C-reactive protein (CRP) are recognized as potential biomarkers for cardiovascular risk.

Purpose of the Study:

  • To investigate serum adiponectin and CRP levels in patients with angiographically defined coronary artery disease (CAD).
  • To assess the relationship between these biomarkers and the severity of coronary lesions.

Main Methods:

  • A cross-sectional observational study included 100 CAD patients and 45 controls.
  • Coronary angiography was used to define CAD and assess lesion severity using the Gensini score.
  • Serum levels of adiponectin and CRP were measured and analyzed using logistic regression.

Main Results:

  • CAD patients exhibited significantly lower serum adiponectin (2.1±1.2 µmg/dl) and higher CRP (2.8±1.5 mg/dl) levels compared to controls (3.3±1.8 µmg/dl and 0.9±0.4 mg/dl, respectively).
  • No significant differences in adiponectin or CRP levels were found between CAD subgroups.
  • Logistic regression revealed a significant association between Gensini score and both serum CRP (OR: 0.98, 95% CI: 1.05-1.35) and adiponectin levels (OR: 1.15, 95% CI: 1.10-1.25).

Conclusions:

  • Serum CRP levels are elevated, while adiponectin levels are decreased in patients with CAD compared to controls.
  • Both CRP and adiponectin levels demonstrate a significant relationship with the severity of coronary artery lesions.
Abstract

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