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Updated: Jun 3, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Association of interleukin-6 gene polymorphism with angina pectoris
Fernanda Gobbi Amorim1, Bianca Prandi Campagnaro, Clarissa Loureiro Tonini
1Biotechnology Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Av. Marechal Campos 1468, Vitoria, Espirito Santo, Brazil.
Abstract:
In this study, we investigated the role of the -174G>C polymorphism of interleukin-6 (IL-6) as a predisposing factor to angina pectoris. Patients were separated into 2 groups: angina (N = 72) and nonangina (N = 71). There were no statistical differences between groups for all cardiovascular risk factors evaluated. The GG genotype frequency was 18% lower in the angina than in the non-angina group, whereas GC + CC was 18% higher in the angina group (P = .036). The frequency of G allele was 11% lower in the angina than in the nonangina group and C allele was 11% higher in the angina group (P = .043). Patients carrying the C allele showed a 2-fold increased risk for angina pectoris (P = .036). Our study demonstrates a high incidence of the -174G>C polymorphism of the IL-6 gene in patients with angina pectoris compared with those carrying the G allele, reinforcing the contribution of genetic factors to the symptoms of angina pectoris.
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Single Nucleotide Polymorphisms-SNPs
