Long-term patterns of depression and associations with health and function in a panel study of rheumatoid arthritis

Anne Morris1, Edward H Yelin, Pantelis Panopalis

  • 1University of California, San Francisco, CA, USA. annemarie.morris@comcast.net

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Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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